Four scenaria are possible in the NMDs:
1. Neurons do not migrate at all from the ventricles (periventricular heterotopia) or migrate half way (subcortical band heterotopia).
2. Some neurons reach the cortex but large numbers do not. No normal cortical layers are formed (lissencephaly, pachygyria, cobblestone cortex).
3. Neurons over-shoot the cortex and end up in the subarachnoid space (marginal-leptomeningeal glioneuronal heterotopia, cobblestone cortex).
4. The late stage of migration and cortical organization is disrupted (polymicrogyria).
http://www.neuropathologyweb.org/chapter11/chapter11dNMD.html#liss
HELPS IN UNDERSTANDING THIS GROUP OF DISORDERS!!
1. Neurons do not migrate at all from the ventricles (periventricular heterotopia) or migrate half way (subcortical band heterotopia).
2. Some neurons reach the cortex but large numbers do not. No normal cortical layers are formed (lissencephaly, pachygyria, cobblestone cortex).
3. Neurons over-shoot the cortex and end up in the subarachnoid space (marginal-leptomeningeal glioneuronal heterotopia, cobblestone cortex).
4. The late stage of migration and cortical organization is disrupted (polymicrogyria).
http://www.neuropathologyweb.org/chapter11/chapter11dNMD.html#liss
HELPS IN UNDERSTANDING THIS GROUP OF DISORDERS!!
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